The UTLIMATE list of CBD oil benefits: Pain, Stress, Anxiety, Sleep, Depression, Addiction, Inflammation, Diabetes, Seizures, Cancer
- Stress & Anxiety
- Sleep & Insomnia
- Epilepsy & Seizures
- CHRONIC PAIN
- ARTHITIS PAIN
- CANCER TREATMENT PAIN
- MIGRAINE PAIN
- NEUROPATHIC PAIN
- MULTIPLE SCLRESOSIS PAIN
- SKIN PAIN
Here is a powerful statement by Medical News Today.
Researchers compiled the results of multiple systematic reviews covering dozens of trials and studies. Their research concluded that there is substantial evidence that cannabis is an effective treatment for chronic pain in adults.
A separate study in the Journal of Experimental Medicine supports these results. This research suggests that using CBD can reduce pain and inflammation.
The researchers also found that subjects were not likely to build up a tolerance to the effects of CBD, so they would not need to increase their dose over time. They noted that cannabinoids, such as CBD, could offer helpful new treatments for people with chronic pain.Medical News Today
CBD oil can be used for chronic pain, like back pain and nerve pain. The active ingredients in CBD oil targets the endocannabinoid system that is inherent in all people. In a way, it is like humans were desgined to process CBD oil and related products.
Everyone has a cell-signaling system known as the endocannabinoid system (ECS). Some researchers think that CBD interacts with a core component of the ECS — endocannabinoid receptors in your brain and immune system.
Receptors are tiny proteins attached to your cells. They receive signals, mostly chemical ones, from different stimuli and help your cells respond. This response creates anti-inflammatory and pain-relieving effects that help with pain management. This means that CBD oil and other products may benefit people with chronic pain, such as chronic back pain.
One 2018 review assessed how well CBD works to relieve chronic pain. The review looked at studies conducted between 1975 and March 2018. These studies examined various types of pain, including: cancer pain, neuropathic pain, fibromyalgia.
Based on these studies, researchers concluded that CBD was effective in overall pain management and didn’t cause negative side effects.Healthline
Although CBD can cause negative side effects, they tend to be minor things like moderate fatigue, drowsiness, and a dry mouth — and things in that magnitude. Anything that has an effect will also have a side effect. But what they mean — is that it didn’t cause any major side effects that affected the quality of life of the participants.
Just don’t expect CBD oil to be as effective as hardcore pain medication — it is not. If you have severe pain, you might want to aim for CBD oil with THC, as it carries that extra punch.
In animal studies, CBD is effective against arthitis pain. They applied CBD gel on the skin of rats with arthitis, and it reduced both pain and inflammation.
A 2016 study looked at CBD use in rats with arthritis. Researchers applied CBD gel to rats for four days in a row. The rats received either 0.6, 3.1, 6.2, or 62.3 milligrams (mg) per day. The researchers noted reduced inflammation and overall pain in the rats’ affected joints. There were no obvious side effects.
Rats who received low doses of 0.6 or 3.1 mg didn’t improve their pain scores. The researchers found that 6.2 mg/day was a high enough dose to reduce the rats’ pain and swelling.
In addition, rats who received 62.3 mg/day had similar outcomes to the rats that received 6.2 mg/day. Receiving a substantially larger dosage didn’t result in them having less pain. The anti-inflammatory and pain-relieving effects of CBD gel could potentially help people with arthritis. However, more human studies are needed.Healthline
The rats that received a normal therapeutic dose (6.2mg/day) had the same effect as rats that received 10x that (62mg/day). But even the rats that got the insanely large dose got better with no obvious side effects. According to this study, taking 10x the recommended dose of CBD oil is not dangeous.
CANCER TREATMENT PAIN
CBD appears to be effective against the pain that comes from cancer treatment. Like chemotherapy ans radiation.
Some people with cancer also use CBD. Research on mice has shown that CBD can lead to the shrinking of cancerous tumors. However, most studies in humans have investigated the role of CBD in managing pain related to cancer and cancer treatment.
In a 2010 study on cancer-related pain, study subjects received oral sprays of a combination THC-CBD extract. The THC-CBD extract was used in conjunction with opioids. This study revealed that using the extract provided more effective pain relief than using the opioids alone.
A 2013 study on THC and THC-CBD oral sprays had a similar finding. Many researchers from the 2010 study worked on this study as well. More evidence is still needed.Healthline
What could be more important than easing the suffering of those people? In this study, they used a THC rich oral spray as a delivery method, and it reduced pain significantly. After all, CBD oil is just a very convenient delivery system to get those 120+ cannabinoids into the system.
In the following study, CBD compounds with and without THC were tested. Both reduced acute migraine pain by 40-55% at therapeutic doses. They also reduced the amount of migraine attacks by slightly over 40%.
Studies on CBD and migraine are limited. The studies that currently exist also look at CBD when it’s paired with THC, not when it’s used alone. However, results from a 2017 study indicate that CBD and THC can lead to less acute pain and less intense pain for people with migraine. In this two-phase study, some participants took a combination of two compounds. One compound contained 9 percent CBD and almost no THC. The other compound contained 19 percent THC. Doses were taken orally.
In phase I, there was no effect on pain when the doses were under 100 mg. When the doses were increased to 200 mg, acute pain fell by 55 percent. In phase II, participants who received the combination of CBD and THC compounds saw the frequency of their migraine attacks fall by 40.4 percent. The daily dose was 200 mg.
The combination of compounds was slightly more effective than 25 mg of amitriptyline, a tricyclic antidepressant. Amitriptyline reduced migraine attacks by 40.1 percent in study participants. Participants with cluster headaches also found pain relief with the combination of CBD and THC compounds, but only if they’d had a childhood history of migraine.Healthline
Although CBD compounds are considered “safe” and “low-risk”, the most common side effects are: fatigue, diarrhea, changes in appetite, and changes in weight.
Scientists have, in fact, been frustrated by the lack of negative side effects. So they created a study where they force-fed mice extremely large amounts of a synthetic laboratory made cannabis extract — and did see changes in their liver values as a result.
One study on mice concluded that CBD-rich cannabis extract increased their risk of liver toxicity. However, some of the mice had been force-fed very large amounts of the CBD-rich cannabis extract.Healthline
So, what is “neuropathic pain“? Here is the highest ranked definition on Google:
Neuropathic pain is caused by damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body.
The pain is usually described as a burning sensation and affected areas are often sensitive to the touch. Symptoms of neuropathic pain may also include excruciating pain, pins and needles, difficulty correctly sensing temperatures and numbness. Some people may find it hard to wear thick clothes as even slight pressure can aggravate the pain.brainandspine.org.uk
CBD oil and related compounds can be effective against “neuropathic pain”.
Neuropathic pain is pain caused by damage to the nerves. This type of pain is common in diseases such as multiple sclerosis, injuries such as herniated discs, and infections such as shingles. A 2017 review found that CBD helped with chronic neuropathy pain in humans. The researchers looked at 11 randomized controlled trials with 1,219 patients.Medical News Today
This review covered 11 scientific studies for a total of 1219 patients — which is not something to be scoffed at. This is a stong piece of evidence.
MULTIPLE SCLRESOSIS PAIN
A study found CBD oil to be effective against the painful muscle spasms that can result from having Multiple Sclerosis.
Multiple sclerosis (MS) is an autoimmune condition that affects the entire body through the nerves and brain. Muscle spasms are one of the most common symptoms of MS. These spasms can be so strong they cause constant pain in some people.
One report found that short-term use of CBD oil could reduce the levels of muscle spasms a person feels. The results are modest, but many people reported a reduction in symptoms. More studies on humans are needed to verify these results.Medical News Today
Topical CBD was applied by the parents of chilren with a rare skin condition, that causes rashes and blisters over the body.
In a report published in Pediatric Dermatology in 2018, scientists reported three cases of topical CBD (applied as an oil, cream, and spray) use in children with a rare, blistering skin condition known as epidermolysis bullosa.
Applied by their parents, all three people reported faster wound healing, fewer blisters, and improvement of pain. One person was able to completely wean off oral opioid analgesic pain medication. There were no adverse effects reported.verywellhealth.com
There is not much research on the effets of CBD oil on painful skin conditions, but it might be worth a shot. If so, use a lotion or gel with CBD in it.
Stress & Anxiety
A couple scientists sat down and reviewed what effect CBD had on stress and anxiety.
According to the authors of one 2015 review, CBD interacts with the cannabinoid type 1 receptor (CB1R), and other receptors in the brain that regulate fear and anxiety-induced behaviors.
The authors of the review also found preclinical and clinical evidence that established CBD as an effective treatment for numerous types of anxiety disorders, including:
–generalized anxiety disorder (GAD)
–post-traumatic stress disorder (PTSD)
–panic disorder (PD)
–obsessive-compulsive disorder (OCD)
–social anxiety disorder (SAD)Medical News Today
A more recent study looked at 397 participants in New Zeeland.
In a more recent 2020 study, researchers evaluated CBD’s effects in 397 adults living in New Zealand. The study participants received medical CBD prescriptions for a variety of ailments, including non-cancer pain, cancer-related symptoms, neurological symptoms, and mental health symptoms.
All groups reported improvements in their overall quality of life after 3 weeks of CBD treatment. The individuals who received CBD treatment for anxiety or depression reportedly experienced improvements in their ability to perform daily functions and reduce pain and anxiety or depression symptoms.
70% of study participants reported some level of satisfaction with CBD treatment, ranging from good to excellent. Only 9.9% of participants experienced adverse side effects, such as sedation and vivid dreams. An even smaller portion of the study population (0.8%) reported worsening symptoms.Medical News Today
And yet another study carefully looked at 72 adults with anxiety or sleep disorders.
In a retrospective study, researchers evaluated the effects of CBD treatment in 72 adults with either anxiety or sleep problems. The majority of study participants received one 25 milligram capsule of CBD once a day (mg/d). A few participants received 50 or 75 mg/d. One individual with a history of trauma and schizoaffective disorder received up to 175 mg/d.
After the first 2 months of CBD treatment, 78.1–79.2% of participants reported improvements in anxiety symptoms. However, 15.3–19.5% of participants developed worse symptoms after CBD treatment.Medical News Today
This might be an effect of giving some participants very large doses. The more common method is to give the same dose to everyone.
The authors of this paper thoroughly reviewed eight studies of CBD and anxiety.
The authors found evidence to support the use of CBD as an effective monotherapy or complementary therapy for treating generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder.
However, the studies showed considerable variation in CBD doses, ranging from 6-400 mg per dose. This variation highlights the need for more high-quality, large-scale clinical trials to help establish standardized dosing and clinical usage guidelines for CBD therapy.Medical News Today
This second paragraph is a comment on the doses which I commented on above. This study used fairly large doses of CBD on 57 males.
In a 2019 study, researchers found that 300–600 mg of CBD significantly reduced anxiety symptoms in 57 adult males.Medical News Today
CBD also shows promise with PSTD (Post-Traumatic Stress Disorder).
CBD may also benefit people with other forms of anxiety, such as social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD). It may help treat anxiety-induced insomnia as well. In 2011, a study researched CBD’s effects on people with SAD. Participants were given an oral dose of 400 milligrams (mg) of CBD or a placebo. Those who received CBD experienced overall reduced anxiety levels.
Multiple recent studies have shown that CBD can help with PTSD symptoms, such as having nightmares and replaying negative memories. These studies have looked at CBD as both a standalone PTSD treatment as well as a supplement to traditional treatments like medication and cognitive behavioral therapy (CBT).Healthline
There are a lot of studies, there isn’t enough space here for all of them. CBD also seems to work for animals. It reduces the level of stress expressed by rats in cages. Which, when you think about it, is like being in prison.
For generalized anxiety disorder (GAD), the National Institute on Drug Abuse (NIDA) says that CBD has been shown to reduce stress in animals such as rats. Study subjects were observed as having lower behavioral signs of anxiety. Their physiological symptoms of anxiety, such as increased heart rate, also improved.Healthline
I believe thousands of studies have been done on how CBD (cannabidiol) affects animals. Most of them find a calming or soothing effect.
The most common side effects are: drowsiness, decreased appetite, diarrhea, changes in weight.
Sleep & Insomnia
CBD oil has hundreds of active ingredients called cannabionoids. The compound called “CBD” is simply the post potent and most well reasearched out of all these compounds.
Cannabidiol — also known as CBD — is one of the main cannabinoids in the cannabis plant. Cannabinoids interact with your endocannabinoid system, which helps your body maintain a state of balance and stability, or homeostasis.
Unlike tetrahydrocannabinol (THC), CBD isn’t psychoactive, meaning it won’t get you “high.” Instead, it has a range of health applications, like reducing seizures in people with epilepsy and pain relief from various conditions.
Some research and anecdotal evidence suggest that CBD can also help you get a good night’s sleep. Here’s what you need to know about using CBD for sleep.Healthline
Okay, let’s get to the actual research. This study looked at both sleep and anxiety, wich are correlated.
Go to source published in 2019 looked at whether CBD could improve sleep and or reduce anxiety. The study involved 72 subjects, with 47 experiencing anxiety and 25 experiencing poor sleep. The subjects were each given 25 milligrams (mg) of CBD in capsule form each day. In the first month, 79.2 percent of the patients reported lower anxiety levels and 66.7 percent reported better sleep.Healthline
So according to this small study, CBD oil will help two out of three people sleep.
This particular study looked at the REM sleep quality of four patients with parkinsson disease.
Other research tells us that CBD affects the sleep cycle. Research from 2014 looked at four patients with Parkinson’s disease. It found that CBD improved the symptoms of REM sleep behavior disorder (RBD), a disorder in which a person acts out their dreams. RBD is associated with poor sleep and nightmares.Healthline
This type of study is so expensive that you cannot do it on large groups of people. In order to scientifically monitor sleep, you have hook them up to all these machines while they sleep.
CBD might also prevent groggines as a result of sleep deprivation.
Grogginess, another symptom of insomnia, might also be affected by CBD. A 2014 review found that CBD could have the potential to promote wakefulness, based on both human and animal research. The authors noted they weren’t sure exactly how or why CBD promoted wakefulness in some instances.Healthline
The authors of this study did not understand why or how CBD promoted wakefulness.
Here are some studies from a Medical News Today article on CBD and sleep.
One investigation found that, compared with a placebo, a CBD dosage of 160 milligrams (mg) increased sleep duration. The researchers also concluded that the placebo, 5 mg of the insomnia drug nitrazepam, and 40, 80, and 160 mg of CBD helped the participants fall asleep.Medical News Today
Some people cannot fall asleep because of high levels of the stress hormone cortisol (which converts protein to sugar).
In one study on the effects of CBD, researchers found that cortisol levels decreased more significantly when participants took 300 or 600 mg of CBD oil. These results suggest that CBD affects the release of cortisol, possibly acting as a sedative.Medical News Today
In this study they measured the sleep quality of 103 participants.
A more recent analysis of CBD and sleep recruited 103 participants who had anxiety or poor sleep. The researchers studied the effects of CBD combined with those of other prescribed medications. The CBD dosages ranged from 25–175 mg. The researchers found that 25 mg was the most effective dosage for anxiety and that addressing troubled sleep required higher dosages.
At the follow-up, 66.7% reported an improvement in sleep, but 25% had worsened sleep.Medical News Today
All in all, 67% reported better sleep and 25% reported worse sleep. Differerent people need different dose. Start low and build up. It can take a month for the full effect to show itself. It does not happen immediately like with benzos. CBD oil and related compounds is not considered addictive.
As a safety precaution, you always want to know what could happen if you accidentally overdosed. In this study, they gave the participants enough CBD to take out a rhino.
Taking 10–400 mg of CBD per day for a long period and by different routes did not have a toxic effect on participants in a large retrospective study. Even dosages of up to 1,500 mg per day were well-tolerated, other researchers report.Medical News Today
But even that has no overt negative side effects. For that reason, CBD oil is one of safer supplements out there.
It is important to understand that CBD oil has over 120 active compounds that might or might not have a healing effect on the human body. It is called “CBD” oil simply because CBD is the most prevalent and potent of these compounds. But when you take CBD oil, you are in fact ingesting all of these compounds into your body.
The text below references an animal study and then a review of existing studies.
Experts believe that CBD’s potential benefits for depression are related to its positive effect on serotonin receptors in the brain. Low serotonin levels are likely connected to depression. CBD doesn’t necessarily boost serotonin levels, but it may affect how your brain’s chemical receptors respond to the serotonin that’s already in your system.
A 2014 animal study found that CBD’s effect on these receptors in the brain produced both antidepressant and anti-anxiety effects.
A more recent 2018 review of existing studies concluded that CBD has anti-stress effects, which may reduce depression related to stress.
As mentioned, this is an area that’s still being actively studied, and new research and reviews are published every year. As researchers begin to better understand CBD and its potential benefits or concerns, information about how to most effectively use the product will continue to change.Healthline
There has been some studies comparing CBD to traditional anti-depressants.
When it comes to treating depression, CBD does appear to have some benefits over antidepressant medications. Most antidepressant medications take weeks to start working.
However, a 2019 animal study found that CBD has a fast and sustained antidepressant-like effect. CBD may also result in fewer side effects than antidepressant medication. Insomnia, sexual dysfunction, mood swings, and agitation are common side effects of antidepressants. CBD has not shown similar issues.Healthline
Since depression and anxiety often occur together, the following study treated both with fairly high doses of CBD.
Depression and anxiety commonly occur together, and people with one are more likely to have the other. CBD does appear to help with both.
One study found that people who took 600 milligrams (mg) of CBD experienced significantly less social anxiety than people who took a placebo.
Another study used a smaller dose of 300 mg, which still reduced levels of anxiety. Anxiety may also have a link to low serotonin, so CBD’s effect on serotonin receptors might partly explain these beneficial effects.Healthline
The most common side effects were fatigue, diarrhea, and changes in appetite or weight.
While CBD can be taken daily as a supplement at low-to-moderate doses, it can also be taken for an acute relief of depressive symptoms.
For example, a 2018 study on rats published in NeuroscienceNews showed that just a single dose of CBD helped to reduce symptoms of depression for up to one week. Researchers believe CBD helps repair neural circuitry in the prefrontal cortex and hippocampus, which get damaged as a result of depression.Health Central
Ketamine is sometimes administered this way at phychiatric wards to suicidal patients. A couple years ago, Ketamine became av over-the-counter prescription mediation depression here in Sweden, but it is still very hard to get. As I understand it, you have to be suicidal or very sick to get it.
CBD interacts with the serotonin receptors in the brain.
CBD may also have a positive interaction with serotonin receptors in the brain. In a study on mice published in CNS & Neurological Disorders, researchers found that when depressed rodents were given CBD, it impacted the way their brains’ chemical receptors responded to serotonin, producing an antidepressant effect.Health Central
All in all, CBD does a lot of different things that seems to reduce the severity of a depression. It is not a miracle cure, but it is an interesting compound that needs more research.
Recently, CBD has received a lot of attention due to its potential to treat drug and alcohol abuse. Literature focuses on the pharmacotherapeutic potential of CBD in terms of its relevance in prevention of relapse in drug use.
It is thought CBD is effective in targeting risk states of drug use relapse by reducing anxiety and stress related to drug cues and mediating anti-depressant activity. In addition to that, CBD has an impact on the brain circuitry that is responsible for drug craving and seeking behaviours triggered by drug-related context and stress.News Medical
In this study, they gave CBD to active heroin addicts. In A Clockwork Orange type setup, they divided heroin addicts into groups. One group watched beatiful nature videos that created a calm state, and the other one watched insane party and drug videos designed to induce cravings and relapse. Who made this study??!!
A recent study published in the American Journal of Psychiatry, led by Yasmin Hurd, further demonstrates the ability of CBD to reduce cravings in people with heroin drug addiction. The study involved 42 women and men with history of heroin abuse attempting to abstain from relapse.
As part of the experiment participants were shown two types of videos: neutral videos showing nature scenes and videos showing drug-related cues aiming to trigger drug cravings.
The participants were divided into three groups: people who took 400mg of CBD, people who took 800mg of CBD and a placebo group. The interventions were taken for three consecutive days. The experiment was double-blinded, meaning that neither the researchers, nor the participants were aware of which conditions they were assigned to during the experiment.News Medical
As you can see, I am not making this up.
Participants experienced higher cravings after seeing the heroin related videos as compared to the neutral videos as expected. However, those participants who took CBD as part of the treatment reported less drug cravings than people in the placebo group after exposure to drug-related cues.
Results also demonstrate reduction in anxiety as well as reduction in heart rate and cortisol which is the “stress hormone”. The effects on the intervention were visible as soon as one hour after administration of CBD and were still visible up to one week after the intervention.News Medical
Large doses of CBD seems to affect the nervous system of the person for about one week after it is given. I have seen this time frame in several other places.
Here is an informative text on the study above in plain language and with colourful graphs. The organisation behind it is called Recovery Research Institute and is a non-profit organisation.
- Study finds that cannabidiol (CBD) reduces drug craving and anxiety in patients recovering from heroin use disorder
In the past decade, there has been an unprecedented spike in opioid use disorder, which has led to more than 300,000 opioid-related deaths in the United States.
The small, experimental study here shows a potential benefit of CBD in reducing cue-induced craving and anxiety in heroin-abstinent individuals. This suggests a potential role for CBD in relapse prevention of heroin use disorder.Recovery Research Institute
A bunch of scientists reviewed 14 studies that looked at CBDs effect on addiction and drug relapse.
In all, 14 studies were found, 9 of which were conducted on animals and the remaining 5 on humans. A limited number of preclinical studies suggest that CBD may have therapeutic properties on opioid, cocaine, and psychostimulant addiction, and some preliminary data suggest that it may be beneficial in cannabis and tobacco addiction in humans.NCBI
Further down the page, they reveal a synergistic effect between CBD and THC.
A synergic effect was revealed when CBD was combined to THC, which reduced the abstinence score to a greater extent than THC alone. They found that CBD potentiated the THC-induced reduction in abstinence score.NCBI
They use the “abstinence score” to measure the severity of the withdrawal symptoms.
In one of these 14 studies (described further down), they made mice addicted to morphine by giving them large amounts of it. Then they gave them naloxone which is an antidote to opioids, creating withdrawal after a short delay. Then the mice would jump off a platform and shit themselves as a result.
The dose of naloxone required to provoke 50% of the mice to jump off of a platform was recorded during the withdrawal, as were defecation and rearing behaviors. CBD inhibited the naloxone withdrawal–induced jumping and reduced defecation and rearing behaviors.NCBI
CBD inhibited both the suicide jumping and the humiliating defecation. Overall, they conclude:
Overall, CBD was found to have an impact on the intoxication and relapse phase of opioid addiction.NCBI
This could also be called “tobacco addiction” or “nicotine addiction”.
In another one of these 14 studies, they put 24 heavy smokers in a lab, and gave half of them CBD and the other half placebo. Then they measured their cravings and smoking activity.
The results showed a significant reduction in the number of cigarettes smoked (≈40%) in the CBD inhaler group during the week of treatment, with a trend indicating a reduction after follow-up.NCBI
CBD reduces cravings in people with a smoking and nicotine addiction by about 40%.
They also found that CBD was safe to combine with alcohol. There was no synergistic effect between them. They also found CBD to be very effective in reducing withdrawal symptoms of marijuana addiction. Which is interesting.
In a case study of a 19-year-old female with severe cannabis dependence, they gave her CBD for the first 11 days of quitting cannabis.
They conducted an experimental trial on a 19-year-old female with cannabis dependence, who experienced withdrawal syndrome when she tried to cease cannabis use. CBD was administered for 11 days (300 mg on day 1, 600 mg on days 2–10, and 300 mg on day 11).
Marijuana Withdrawal Symptom Checklist, Beck Anxiety Inventory, and Beck Depression Inventory showed a rapid decrease in withdrawal symptoms, leading to a score of zero in all tests by day 6NCBI
Once they started giving her CBD, her withdrawal symptoms started declining. By day 6, they were completely gone. A 6-month follow up showed a relapse to smoking 1-2 days a week, where before she was smoking every day.
CBD oil appears to work on both acute and chronic inflammation.
There’s research to suggest that CBD reduces inflammation by affecting activity in the body’s endocannabinoid receptors. That goes for both chronic inflammation and acute inflammation. A study on rats found that CBD reduced inflammation in rats with osteoarthritis. A 2009 review shows CBD may also reduce acute inflammation, which is most often the body’s reaction to an injury.Healthline
This study found that CBD reduced pain and inflammation (which often appear together).
In the study quoted below, they applied a CBD gel on rats with arthritis — at small, medium, and large doses. They found that the small dose of 6.2 has the same anti-inflammatory effect as the dose 10x that of 62.
The researchers noted reduced inflammation and overall pain in the rats’ affected joints. There were no obvious side effects. Rats who received low doses of 0.6 or 3.1 mg didn’t improve their pain scores.
The researchers found that 6.2 mg/day was a high enough dose to reduce the rats’ pain and swelling. In addition, rats who received 62.3 mg/day had similar outcomes to the rats that received 6.2 mg/day.
Receiving a substantially larger dosage didn’t result in them having less pain. The anti-inflammatory and pain-relieving effects of CBD gel could potentially help people with arthritis. However, more human studies are needed.Healthline
Other research has indicated that it takes about a month for the full effect of CBD to show itself in a treatment cycle. According to this, you want to take a low dose over a long period of time.
In 2015, a bunch of scientists sat down and did a review of some of the studies on CBD and inflammation.
A 2015 review published in Bioorganic and Medicinal Chemistry discussed the anti-inflammatory properties of CBD. The reviewers found that CBD reduces inflammation through several pathways in the body, and represents an effective potential treatment for a range of conditions characterized by inflammation.Weed Maps
Here is a direct link to that review:
This other study looked at CBDs effect on pancreatic inflammation in diabetic mice.
A 2016 study published in Clinical Hemorheology and Microcirculation investigated CBD as a treatment for early pancreatic inflammation in diabetic mice. Pancreatic inflammation can lead to diabetes due to an invasion of immune cells that destroy insulin-producing cells. The mice who received 10 weeks of treatment with CBD developed diabetes later than the mice that didn’t receive the treatment. CBD-treated mice also showed a significant reduction in immune-cell activity.Weed Maps
The mice who got CBD had better blood sugar control than the mice who didn’t get it. They had less inflammation in their pancreas. Less diabetes. Here is a direct link to that study:
This particular study applied CBD locally to problem areas of arthritic mice.
A 2017 study in the journal Pain examined the effects of CBD in male rats with osteoarthritis. After two weeks, acute inflammation of the joints was reduced by local CBD treatment applied to the area. The administration of CBD was also found to prevent the development of nerve damage and joint pain.Weed Maps
It also prevented nerve damage and joint pain. Here is a direct link to that study:
- Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis
While CBD is not a miracle cure, it does appear to be effective against both chronic and acute inflammation.
CBD helps normalize blood sugar levels.
The benefits of CBD for treating diabetes-related health problems may include reduced inflammation and improved blood glucose control. Meanwhile, in 2016, University of Nottingham researchers showed that CBD in combination with another cannabis compound called tetrahydrocannabivarin (THCV), helped lower blood sugar levels and increase insulin production in people with type 2 diabetes.diabetes.co.uk
So — what is THCV? THCV is a compound naturally present in cannabis that seem to have many health benefits. Here is a short list:
- THCV is an appetite suppressant
- THCV may help with diabetes
- THCV may reduce panic attacks
- THCV may help with Alzheimer’s
- THCV stimulates bone growth
Find the full list in this article: What Is THCV and What Are the Benefits of This Cannabinoid?
It is important to understand that CBD oil is made from industrial hemp and has over 120 different biologically active cannabinoids. CBD (cannabidiol) is just the most prevalent (40% of plant extract) and well researched one of all those compounds. But likely, most of them have some type of health benefit to the human body. The problem with the names is that they are so similar. It’s confusing!
This particular study was cited under the chapter “Inflammation” because it involved giving CBD to mice with inflammation in the pancreas. They would expose groups of mice to specific conditions that give them diabetes. They would give one of the groups CBD to see if it made a difference.
A 2016 study published in Clinical Hemorheology and Microcirculation investigated CBD as a treatment for early pancreatic inflammation in diabetic mice. Pancreatic inflammation can lead to diabetes due to an invasion of immune cells that destroy insulin-producing cells. The mice who received 10 weeks of treatment with CBD developed diabetes later than the mice that didn’t receive the treatment. CBD-treated mice also showed a significant reduction in immune-cell activity.Weed Maps
The mice who got CBD got diabetes at a much later stage. Which indicates that CBD delays the onset of diabetes — at the very least.
I’ve had to use my ultimate form as keyboard warrior to find these rare studies on CBD and diabetes. There are 44.7 million total search results for “CBD oil + diabetes” on Google — but only a couple studies.
CBD doesn’t seem to have a dramatic effect on blood sugar levels. This study out of the UK found that the active compound THCV (mentioned above) had a significant impact on blood sugar levels, while CBD did not. Check this out:
Early research suggests CBD and diabetes are indeed worth further study. For example, a small study published in October 2016 in Diabetes Care in the United Kingdom looked at 62 people with type 2 diabetes and found that CBD did not lower blood glucose. Participants were not on insulin, but some took other diabetes drugs.
They were randomly assigned to five different treatment groups for 13 weeks: 100 milligrams (mg) of CBD twice daily; 5 mg of THCV (another chemical in cannabis) twice daily; 5 mg CBD and 5 mg THCV together twice daily; 100 mg CBD and 5 mg of THCV together twice daily; or placebo. In their paper, the authors reported that THCV (but not CBD) significantly improved blood glucose control.Everyday Health
In another study, they looked at the blood sugar levels of marijuana smokers vs non-smokers.
Epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared with people who have never used marijuana.
To date, no study has investigated the relationship between marijuana use and fasting insulin, glucose, and insulin resistance.The American Journal of Medicine
Here they basically saying that it’s long been known that marijuana smokers are slimmer and less fat. They aren’t obese and they don’t have diabetes as often.
In the results section they wrote this:
Of the participants in our study sample, 579 were current marijuana users and 1975 were past users. Current marijuana use was associated with 16% lower fasting insulin levels.
We found significant associations between marijuana use and smaller waist circumferences. Among current users, we found no significant dose-response.The American Journal of Medicine
The slim weedsmoking guy might be a stereotype for a reason? Because most marijuana users are slim or at least not obese. These cultural stereotypes often have a grain of truth in them.
Some patients use CBD to deal with the nerve pain that comes from diabetes.
In Nevada, where Dr. Brady used to work as a certified diabetes educator, her patients with type 2 diabetes used CBD for nerve pain. She says patients would use CBD in a tincture or in oils that they rubbed on painful areas, including their feet. Patients could buy CBD at medical marijuana dispensaries, which would offer dosing instructions. “They worried about the impact on their blood sugars,” says Brady.
Ultimately, though, Brady says that her patients reported that CBD reduced their nerve pain and improved their blood sugar. She adds that those people who used CBD oils for nerve pain also reported sleeping better.Everyday Health
If you have a tool that makes you relax and feel good, you might not have to rely on comfort eating as much. I think that is why CBD and marijuana makes people lose weight.
Epilepsy & Seizures
It isn’t known exactly how CBD helps prevent seizures. Your body contains a system of neurotransmitters and receptors called the endocannabinoid system. This system is thought to help regulate functions in your body such as appetite, sleep, and pain, as well as your immune system response. It’s thought that CBD can modify these functions by interacting with receptors in your endocannabinoid system.
Animal research suggests CBD’s antiseizure effects might come from reducing neuron excitability by acting on two groups of receptors called GPR55 and TRPV1 receptors.
Currently, a prescription drug CBD called Epidolex is approved by the Food and Drug Administration (FDA) to treat Lennox-Gastaut and Dravet syndromes, two rare forms of epilepsy. It’s also FDA-approved to treat seizures caused by the genetic disorder tuberous sclerosis complex.Healthline
Both CBD oil and marijuana shows great promise in preventing epilepsy and seizures. Social media is filled with dramatic before/after examples. Weed in all forms is inherently a “downer”, as it down-regulates the body, and its various functions.
In the first study, researchers compared the antiseizure effect of 20 milligrams per kilogram (mg/kg) of Epidolex per day with a placebo. They found:
—Half of the participants who took Epilolex experienced 44 percent fewer seizures.
–Half of the participants in the placebo group experienced 22 percent fewer seizuresHealthline
—Half the participants who took 20 mg/kg of Epidolex per day experienced 42 percent fewer seizures.
—Half the participants who took 10 mg/kg per day experienced 37 percent fewer seizures.
–Half the participants in the placebo group experienced 17 percent fewer seizures.Healthline
In both of these studies we see a clear correlation between the strengh of the CBD medication and a reduction in seizures. This is a strong piece of evidence that CBD works for epilepsy and seizures.
The same CBD medication mentioned above, Epidolex, was used in another study to treat a form of epilepsy called “Dravet syndrome“.
Dravet syndrome is a rare form of epilepsy that causes seizures that don’t respond well to medication.
In a clinical trial, researchers compared the effect of 20 mg/kg of Epidolex taken daily with a placebo in participants age 2 to 18.
The researchers found that participants who took Epidolex experienced a significant drop in seizure frequency (39 percent decrease), compared with the placebo group (17 percent decrease).Healthline
The CBD medication reduced seizures far more than placebo.
In another study, CBD was given to people with four different kinds of epilepsy.
A 2018 study examined the effect of CBD on 55 people with one of four types of epileptic syndromes:
–CDKL5 deficiency disorder
At baseline, the participants had an average of 59.4 seizures per month. After 12 weeks, the average went down to 22.5 per month. The improved rate persisted over the entire 48 weeks of the study.Healthline
The result of this study is extremely impressive. It reinforces the idea that CBD works on many (or even most) types of epilepsy. That is a percentage reduction of 62%. That is insane!
Cannabinoids have the potential to be used as an anti-inflammatory for skin conditions, with possible anti-cancer effects. Skin inflammation often leads to an increased risk of skin cancer due to increased pro-inflammatory cytokines and activation cascades, amongst other factors.
Cannabinoids have been shown to combat this and produce anti-inflammatory effects, acting as protective agents in neuroinflammatory disorders, making them an excellent candidate for skin cancer treatment.Open Access Government
Here are two studies that shows this:
- Cannabinoids in the Pathophysiology of Skin Inflammation
- Cannabinoids and innate immunity: taking a toll on neuroinflammation
Here are two studies that showed CBD to inhibit canncer cell growth and reduce tumor volume.
A 2014 study looked at experimental models of colon cancer in vivo and suggested that CBD may inhibit colorectal cancer cell proliferation, and it had no effect on healthy cells(. Similarly, a 2019 study showed CBD to induce apoptosis by regulating various anti- and pro-apoptotic proteins, decreasing overall tumor volume.Open Access Government
- Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol
- Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells
Cannabinoids are effective against the highly deadly breast cancer.
In females, breast cancer is a leading cause of death and the most common cancer worldwide. Cannabinoids have shown to have a modulatory effect on hormone-sensitive breast cancer cells by involving themselves within receptor-dependent and independent regulation of invasion and proliferation, both crucial hallmarks of cancer growth. In particular, CBD was shown to ultimately result in activation of the intrinsic apoptotic pathway present in breast cancer cells, leading to cell death.Open Access Government
CBD oil does appear to be effective versus lung cancer.
Lung cancer is another cancer with a high prevalence and mortality rate worldwide. Ninety percent of lung cancers can be attributed to tobacco smoking, amongst other factors, such as exposure to chemical agents or radiation.
A recent study showed the expression levels of cannabinoid receptors to be a potential marker of survival in patients with non-small cell lung cancer. CBD was also able to inhibit the expression and growth of epidermal growth factor receptors in lung cancer cells.Open Access Government
This language is overly complicated, but basically, CBD increases your survival rate if you have lung cancer.
- Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro
Further down the page, it talks about CBD oils’ possible role in preventative cancer treatment. Since cancer can get out of control quickly once it starts to spread.
With the rise in the prevalence of numerous cancers, more attention has been given to preventing this disease. It is well acknowledged that cancer development is highly influenced by lifestyle choices, such as diet, exercise, and stress levels. Prevention of cancer is vital, as once the tumor cells start to spread and increase it can be very rapid and uncontrollable. There is also a higher chance of eliminating the cancer cells by chemotherapy or radiation if caught at an earlier stage.Open Access Government
Several lifestyle factors determine the likelihood of getting cancer.
Some common preventative treatments include a healthy diet with lots of fruits and vegetables, avoiding tobacco, maintaining a healthy weight, and regular screenings and self-exams, especially for breast and skin cancer. Most of these cancer prevention techniques are useful, as they help lower several key risk factors for developing cancer. These include elevated blood pressure, high cholesterol levels, inflammation within the body, and obesity.Open Access Government
CANCER TREATMENT SIDE EFFECTS
CBD oil can dampen the harsh side effects of cancer treatment. Especially chemotherapy and radiation. Marijuana (with THC) has long been used to dampen the pain and nausea that comes from cancer treatment.
Since CBD oil with THC is more potent in studies, since CBD and THC has a synergistic effect, consider getting a CBD oil with THC — if that is legal where you live.
Perhaps one of the most challenging stages of patient care required for individuals with cancer is dealing with the numerous side effects of the cancer disease itself and subsequent treatments.
Cancer treatment options are vast, but they can include hormone therapy, immunotherapy, and chemotherapy. These treatments are highly taxing on the body and often result in a myriad of side effects, including insomnia, nausea, decreased appetite, and chronic pain.Open Access Government
One common problem is insomnia.
INSOMNIA: Insomnia can be triggered by certain medications, which can disturb your natural sleep-wake cycle. This can then lead to excessive grogginess and fatigue during the day, with increased feelings of anxiety, since insufficient sleep is often linked to poor mental health. CBD may help encourage the feeling of sleeplessness in individuals on cancer medications, therefore regulating their circadian rhythm.
A large case study published in 2019 looked at whether CBD could reduce anxiety and improve sleep in 72 individuals. After a month of consuming one CBD capsule daily, around 67% of patients reported better sleep and 80% reported lowered anxiety levels.Open Access Government
Poor appetite and nausea is a common side effect from cancer treatment.
APPETITE: Appetite loss, poor appetite, and nausea are some of the most common side effects of cancer treatment. Long-term appetite complications can be detrimental to the patient, as they could lead to insufficient nutrient intake and fatigue due to muscle loss. Most studies that research the relationship between CBD and appetite have varying data, with some showing weight gain and others showing distinct weight loss. Despite the inconclusive research, one thing is for sure: these effects on hunger and appetite vary depending on the individual, their genetics, and the type of CBD product used.Open Access Government
Changes in appetite is usually listed as a negative side effect from CBD oil, but if you lack appetite and need to eat — increased hunger wouldn’t be so bad.
PAIN: Chronic and persistent pain can be highly debilitating to the cancer patient’s quality of life. The research on topical CBD products like CBD oil and their effects on pain management has been promising, with many recent studies showing CBD oil’s role in reducing inflammation and overall discomfort due to various health conditions like cancer.
A 2018 review looked at studies conducted from 1975 to 2018 to assess how CBD works in relieving chronic pain. A range of pain conditions was examined, including neuropathic and cancer pain. It was concluded that CBD was effective in overall pain management across the field, with little to no adverse side effects.Open Access Government
CBD is effective versus pain, but the effect is much more sublte than what you see with strong medication or hardcore drugs. Strength wise, it is not comparable to morphine or benzos.
But it is a good tool in the toolbox, that induces a mild healing reaction in your entire body. There are no major negative side effects, even at 10x the normal therapeutic dose.